Physiology & Pharmacology
Seyed Arman Razavi; Amin Bigham-Sadegh; Iraj Karimi; Siavash Sharifi; Iman Hafar
Volume 28, Issue 3 , May and June 2021, , Pages 387-395
Abstract
Introduction: Phenytoin ointment is a usual medicine for wound healing. Aloe vera gel promotes wound healing by directly stimulating the activity of macrophages and fibroblasts that increase both collagen and proteoglycan synthesis, thereby promoting tissue repair. The aim of this study was to evaluate ...
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Introduction: Phenytoin ointment is a usual medicine for wound healing. Aloe vera gel promotes wound healing by directly stimulating the activity of macrophages and fibroblasts that increase both collagen and proteoglycan synthesis, thereby promoting tissue repair. The aim of this study was to evaluate the effects of phenytoin ointment1%, aloe vera gel, royal jelly and honey on skin wound healing in rabbit animal model. Materials and Methods: 5 rabbits with 50 skin wounds were used in this study. Phenytoin ointment1%, aloe vera gel, royal jelly and honey were used in four wounds and another was considered as an untreated control. Macroscopic study was performed on days 4, 8, 12, 16 and 20 after wounding and histopathologic study was done on the days 10 and 21 from the wounds. Results: On the 8th and 12th days in the Aloe vera gel, royal jelly and honey groups, the area of the wound had a significant difference (p < 0.05) than group1 (phenytoin), indicating a faster reduction of the wound surface than the phenytoin group. On the 16th day after surgery, the ulcer surface of the honey group was completely closed and on day 20 all the wounds were fully restored in all groups. Also, histopathologic studies on 10 and 21 days showed no significant difference between the studied groups and all wounds were completely restored on day 20. Conclusion: Finally, the results of this Study showed that phenytoin 1% ointment, aloe vera gel, royal jelly and honey, all had a good effect on wound healing.
Biophysics & Radiotherapy
Mehrdad Yadegari; Amin Bigham-Sadegh; Ali Saberi; Ali Parvizi; Elham Moghtadaiee-Khorasgani
Volume 27, Issue 3 , September and October 2020, , Pages 483-491
Abstract
Introduction:Tendon rupture is one of the most common problems in livestock and human. Tendon has a special blood flow network that is fed from outside to inside. The most important factor in tendon healing is blood flow which is very slow. Various methods that have been implemented to treat and repair ...
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Introduction:Tendon rupture is one of the most common problems in livestock and human. Tendon has a special blood flow network that is fed from outside to inside. The most important factor in tendon healing is blood flow which is very slow. Various methods that have been implemented to treat and repair these raptures are time-consuming.
Materials and Methods: 10 male New Zealand rabbits with weight 1-2/5 kg were selected and kept for one month. The posterior organs of the rabbits were shaved and anesthetized. Then, under sterile conditions, the SDFT tendon was cut through the skin, the rabbits were divided into two groups of five and the control group and received three groups of samples at a dose of 1μg/kg of Theranekron, and during the days of 3, 10 And 30 ultrasound examinations. After 30 days, the samples were euthanasia for pathological investigations, and the lesion was removed and sent to the lab.
Results: The results of the thirtieth day of ultrasound examination showed a significant improvement in the tendon fibroblasts, similar to the normal area of the damaged region of echogenicity. Histopathologic results show the beneficial effects of Theranekron during this study. Therefore, the number of collagen fibers accumulated in the tissue in the treated group significantly increased.
Conclusion: It was concluded that Theranekron was effective in healing tendons and reducing inflammation.